Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

Author:

Fallahi‐Sichani Mohammad1ORCID,Becker Verena1,Izar Benjamin23,Baker Gregory J1,Lin Jia‐Ren4,Boswell Sarah A1ORCID,Shah Parin2ORCID,Rotem Asaf2ORCID,Garraway Levi A235,Sorger Peter K145ORCID

Affiliation:

1. Department of Systems Biology Program in Therapeutic Sciences Harvard Medical School Boston MA USA

2. Department of Medical Oncology Dana–Farber Cancer Institute Boston MA USA

3. Broad Institute of Harvard and MIT Cambridge MA USA

4. HMS LINCS Center and Laboratory of Systems Pharmacology Harvard Medical School Boston MA USA

5. Ludwig Center at Harvard Harvard Medical School Boston MA USA

Funder

National Institutes of Health

National Cancer Institute

Life Sciences Research Foundation

Dr. Miriam and Sheldon G. Adelson Medical Research Foundation

Melanoma Research Alliance

Dana-Farber Cancer Institute

Publisher

EMBO

Subject

Applied Mathematics,Computational Theory and Mathematics,General Agricultural and Biological Sciences,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Information Systems

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