A Review of Antibiotic Resistance: Global Reports, Sources, Incidents, Resistance Strategies, and Control Plans

Abstract

Antimicrobial resistance is a major global issue that is only getting worse. Acquired resistance is defined by the emergence of coding genes for strategies of drug evasion from antimicrobial agents. The Enterobacteriaceae family has been linked to this behavior. Antibiotics like beta-lactams and carbapenems, which are the most used types, are used to treat bacterial infections. From a clinical perspective, research on antibiotic resistance is very important because of the effects it has on human health. Furthermore, one of the rare instances of evolution that can be researched in real time is antibiotic resistance. Therefore, doctors, evolutionary biologists, and ecologists are interested in understanding the general processes involved in the acquisition of antibiotic resistance. Environmental microbes are the source of antibiotic resistance genes that are currently found in human diseases. Therefore, research on both natural and medical environments is necessary to fully comprehend the emergence of antibiotic resistance. Recent findings about the evolutionary processes underlying resistance suggest that viability costs, the founder effect, and ecological connectivity are significant barriers that control the spread of resistance from environmental bacteria to diseases.