Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis

Author:

Gao Mengjia1234,Xin Jingxin1234,Li Xiaoling1234,Gao Ling2345ORCID,Shao Shanshan1234ORCID,Zhao Meng1234ORCID

Affiliation:

1. Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China

2. Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong 250021, China

3. Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, Shandong 250021, China

4. Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Jinan, Shandong 250021, China

5. Scientific Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China

Abstract

Nonalcoholic steatohepatitis (NASH) is a liver disease caused by multiple factors, and there is no approved pharmacotherapy. The pathogenesis of NASH remains underexplored. In this study, differentially expressed circular RNAs (circRNAs) were obtained by analyzing NASH-related circRNA datasets, and then, corresponding target microRNAs (miRNAs) and messenger RNAs (mRNAs) were predicted to construct a circRNA–miRNA–mRNA regulatory network. On this basis, a total of 38 circRNAs, 7 miRNAs, and 10 mRNAs were screened out. The present study reveals novel circRNA biomarkers of NASH and reports a potential competing endogenous RNA (ceRNA) regulatory network that might provide insights for further investigation into the underlying pathogenesis of NASH.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

Gastroenterology,Hepatology

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