Comparison of the Saponins in Three Processed American Ginseng Products by Ultra-High Performance Liquid Chromatography-Quadrupole Orbitrap Tandem Mass Spectrometry and Multivariate Statistical Analysis

Author:

Guo Na1,Bai Yuxin2,Huang Xin1ORCID,Liu Xiaokang2,Cai Guangzhi2,Liu Shuying1,Guo Yunlong1ORCID,Gong Jiyu2ORCID

Affiliation:

1. Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China

2. School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, China

Abstract

A method with ultrahigh performance liquid chromatography Quadrupole-Orbitrap tandem mass spectrometry (UHPLC-Q-Orbitrap-MS/MS) was applied for the quality evaluation of different processing and drying of American ginseng, including natural drying (ND), steam drying (SD), and vacuum freeze-drying (VFD). A total of 51 saponins were successfully identified in three processed products. Three processed American ginseng products were well-differentiated in orthogonal partial least-squares discriminant analysis (OPLS-DA). The S-plot also identified the marker compounds in each product, while the major ginsenosides of ND (malonyl (M)-Rd, M-Rb1, Rg1), SD (20 (S)-Rg3, 20 (S)-Rg2), and VFD (M-Rd, M-Rb1) were found. The results indicate that the method by vacuum freeze-drying can retain the content of rare ginsenosides and malonyl-ginsenosides. The marker compounds selected will benefit the holistic evaluation of related American ginseng products.

Funder

National Natural Science Foundation of China

Publisher

Hindawi Limited

Subject

Analytical Chemistry

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