Updates on Antiobesity Effect ofGarciniaOrigin (−)-HCA

Abstract

Garciniais a plant under the family of Clusiaceae that is commonly used as a flavouring agent. Various phytochemicals including flavonoids and organic acid have been identified in this plant. Among all types of organic acids, hydroxycitric acid or more specifically (−)-hydroxycitric acid has been identified as a potential supplement for weight management and as antiobesity agent. Variousin vivostudies have contributed to the understanding of the anti-obesity effects ofGarcinia/hydroxycitric acid via regulation of serotonin level and glucose uptake. Besides, it also helps to enhance fat oxidation while reducingde novolipogenesis. However, results from clinical studies showed both negative and positive antiobesity effects ofGarcinia/hydroxycitric acid. This review was prepared to summarise the update of chemical constituents, significance ofin vivo/clinical anti-obesity effects, and the importance of the current market potential ofGarcinia/hydroxycitric acid.