Involvement of Nrf2 in Ocular Diseases-Reference-Cited by-同舟云学术

Involvement of Nrf2 in Ocular Diseases

Published:2017 Issue: Volume:2017 Page:1-18
ISSN:1942-0900
Container-title:Oxidative Medicine and Cellular Longevity
language:en
Short-container-title:Oxidative Medicine and Cellular Longevity

Author:

Batliwala Shehzad¹,Xavier Christy²,Liu Yang²³,Wu Hongli²³^ORCID,Pang Iok-Hou²³^ORCID

Affiliation:

1. Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX 76107, USA

2. Department of Pharmaceutical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA

3. North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, TX 76107, USA

Abstract

The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system—the Keap1-Nrf2-ARE pathway—on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.

Funder

BrightFocus Foundation

Publisher

Hindawi Limited

Subject

Cell Biology,Ageing,General Medicine,Biochemistry

Link

http://downloads.hindawi.com/journals/omcl/2017/1703810.pdf

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