Real-World Outcomes in Patients with Branch Retinal Vein Occlusion- (BRVO-) Related Macular Edema Treated with Anti-VEGF Injections Alone versus Anti-VEGF Injections Combined with Focal Laser

Author:

Thomley Meredith E.12ORCID,Gross Cole N.3ORCID,Preda-Naumescu Ana12ORCID,Chen Kelly S.12ORCID,Swain Thomas4ORCID,Mason III John O.5ORCID,Crosson Jason N.5ORCID

Affiliation:

1. The University of Alabama, Birmingham School of Medicine, Birmingham, AL 35233, USA

2. Retina Consultants of Alabama, The University of Alabama, Birmingham School of Medicine, Birmingham, AL 35233, USA

3. Ophthalmology Resident at the Callahan Eye Center, University of Alabama, Birmingham Department of Ophthalmology, Birmingham, AL 35233, USA

4. Department of Ophthalmology and Visual Sciences, Birmingham, AL 35233, USA

5. Retina Consultants of Alabama, The University of Alabama, Birmingham Department of Ophthalmology, Birmingham, AL 35233, USA

Abstract

The purpose of this study was to assess outcomes in a real-world nonclinical trial setting of antivascular endothelial growth factor (VEGF) injections alone vs. focal laser combined with anti-VEGF injections in patients with branch retinal vein occlusion- (BRVO-) related macular edema (ME). This study included 88 BRVO with ME patients who were treated over three years at both a tertiary referral center in the Birmingham metropolitan area and satellites in rural Alabama. One group received only anti-VEGF injections (n = 56); the other group received both anti-VEGF injections and focal laser (n = 32). The following outcome measures were evaluated: initial and final visual acuities (VA), initial central subfield thickness (CST) on OCT, number of injections, number of lasers, percentage of patients with a gain of 3 lines of VA, percentage of patients with VA better than or equal to 20/40, and percentage of patients with VA worse than or equal to 20/200. We found that there was no difference in initial VA ( p = 0.913 ) or CST ( p = 0.961 ) between the two groups. The injection only group required a median of 7 injections, while the combination group required a median of 4 injections, but this was not a statistically significant difference ( p = 0.117 ). There was no difference in final VA ( p = 0.414 ) or any of the other visual outcomes between the two groups. In conclusion, focal laser did not decrease the number of injections required or improve the VA in BRVO-related ME. Although visual outcomes were similar in both groups, focal laser does not appear to be of additional benefit in BRVO-related ME in the anti-VEGF era.

Publisher

Hindawi Limited

Subject

Ophthalmology

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