Circulating IL-1β, IL-17, and IP-10 as Potential Predictors of Hepatitis B Virus Infection Prognosis

Author:

Su Zhenzhen1,Chen Jie1,Zhang Junlong1,An Yunfei1,Liao Yun1,Wu Xiaojuan1,Tao Chuanmin1,Wang Lanlan1ORCID,Cai Bei1ORCID

Affiliation:

1. Department of Laboratory Medicine/Research Centre of Clinical Laboratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China

Abstract

Circulating cytokines and chemokines play critical roles in hepatitis B virus (HBV) infection. Here, we explored the effects of proinflammatory and anti-inflammatory effector molecules on HBV progression, e antigen seroconversion, and liver function. Our results showed that circulating interleukin (IL)-17 may be helpful in HBV spontaneous clearance [odds ratio OR = 1.468 , 95 % confidence interval CI = 1.080 1.995 , P = 0.014 ] and protective against HBV-related hepatoma development ( OR = 0.933 , 95 % CI = 0.910 0.957 , P < 0.001 ). IL-1β negatively affected HBV clearance ( OR = 0.052 , 95 % CI = 0.005 0.534 , P = 0.013 ). In patients with chronic hepatitis B, interferon-γ-inducible protein-10 (IP-10) levels significantly increased in the group of abnormal liver function ( P = 0.006 ). Furthermore, positive correlations of IP-10 with alanine aminotransferase and aspartate aminotransferase levels were observed ( r s = 0.546 and 0.644 , respectively; P < 0.001 ). In conclusion, inflammatory cytokines and chemokines may be a “double-edged sword” for HBV clearance and progression. Further exploration of the roles of IL-17, IL-1β, and IP-10 in chronic HBV infection is needed.

Funder

Sichuan Provincial Cadre Health Research Project of the Sichuan Provincial Health Commission

Publisher

Hindawi Limited

Subject

Immunology,General Medicine,Immunology and Allergy

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