Cdc48: A Swiss Army Knife of Cell Biology-Reference-Cited by-同舟云学术

Cdc48: A Swiss Army Knife of Cell Biology

Published:2013-09-15 Issue: Volume:2013 Page:1-12
ISSN:2090-0104
Container-title:Journal of Amino Acids
language:en
Short-container-title:Journal of Amino Acids

Author:

Baek Guem Hee¹,Cheng Haili¹,Choe Vitnary¹,Bao Xin¹,Shao Jia²,Luo Shiwen²,Rao Hai¹

Affiliation:

1. Department of Molecular Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA

2. The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi 330006, China

Abstract

Cdc48 (also called VCP and p97) is an abundant protein that plays essential regulatory functions in a broad array of cellular processes. Working with various cofactors, Cdc48 utilizes its ATPase activity to promote the assembly and disassembly of protein complexes. Here, we review key biological functions and regulation of Cdc48 in ubiquitin-related events. Given the broad employment of Cdc48 in cell biology and its intimate ties to human diseases (e.g., amyotrophic lateral sclerosis), studies of Cdc48 will bring significant insights into the mechanism and function of ubiquitin in health and diseases.

Funder

National Institutes of Health

Publisher

Hindawi Limited

Subject

Molecular Biology,Biochemistry,Molecular Biology,Biochemistry

Link

http://downloads.hindawi.com/archive/2013/183421.pdf

Reference117 articles.

1. Cdc48 (p97): a ‘molecular gearbox’ in the ubiquitin pathway?

2. Growing sphere of influence: Cdc48/p97 orchestrates ubiquitin-dependent extraction from chromatin

3. Cdc48/p97, a key actor in the interplay between autophagy and ubiquitin/proteasome catabolic pathways