Affiliation:
1. Department of Endocrinology, Metabolism and Gastroenterology, Third Affiliated Clinical Hospital to Changchun University of Chinese Medicine, Changchun 130117, Jilin, China
2. College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130117, Jilin, China
3. Department of Cardiology, Third Affiliated Clinical Hospital to Changchun University of Chinese Medicine, Changchun 130117, Jilin, China
Abstract
Objective. To evaluate the clinical efficacy and safety of Gegen Qinlian decoction in the treatment of pediatric diarrhea. Methods. A search for relevant RCTs was performed from which a systematic review and meta-analysis was conducted. This meta-analysis was registered at INPLASY (reference number ID: INPLASY202180105). Results. (1) Eleven trials involving 1126 patients were included in the meta-analysis. (2) Two trials recorded the adverse events. (3) The meta-analysis showed that compared with the control group, the experimental group has a significantly shorter duration of diarrhea in children (MD = −18.64, 95% CI (−23.76, −13.52),
), duration of fever (MD = −19.43, 95% CI (−25.76, −13.11),
), duration of vomiting [MD = −22.51, 95% CI (−29.92, −15.09),
], duration of correcting dehydration (MD = −23.35, 95% CI (−35.48, −11.22),
), and the effective rate (OR = 4.64, 95% CI (3.12, 6.90),
). Conclusion. There were significant differences in the clinical efficacy in the treatment of pediatric diarrhea between the experimental and control groups. Thus, Gegen Qinlian decoction may have certain advantages in the treatment of pediatric diarrhea. In addition, we conclude the following: (1) the application of Gegen Qinlian decoction to treat this disease is recommended for >5 days. (2) We recommend conducting multicenter RCTs to avoid the impact of regional differences on the results. (3) We recommend using the unmodified Gegen Qinlian decoction, which may have better efficacy.
Funder
National Basic Research Program of China
Subject
Complementary and alternative medicine
Reference49 articles.
1. Technical guideline for clinical trial design and evaluation of traditional Chinese medicine for pediatric diarrhea;S.-Y. Hu;Drug Evaluation Research,2020
2. Evidence-based evaluation of global existed diarrhea guidelines of children;Y. Zhang;China Pharmacy,2018
3. Genipin inhibits rotavirus-induced diarrhea by suppressing viral replication and regulating inflammatory responses
4. Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the global burden of disease study 2013;H.-D. Wang;The Lancet,2014
5. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the global burden of disease study 2016;C. Troeger;The Lancet,2018