Association of the Combined Effects between Insulin-Like Growth Factor-1 Gene Polymorphisms and Negative Life Events with Major Depressive Disorder among Chinese population in the Context of Oxidative Stress

Author:

Qiao Zhengxue1ORCID,Xie Yunjia1ORCID,Wu Yongmei1ORCID,Yang Xiuxian1ORCID,Qiu Xiaohui1ORCID,Zhou Jiawei1ORCID,Lu Yuxin1ORCID,Chen Lu2,Tong Yuying3ORCID,Xu Jia4ORCID,Li Jiarui5ORCID,He Jingyun1ORCID,Pan Hui6,Yang Yanjie1ORCID,Yang Jiarun3ORCID,Bu Tianyi1ORCID

Affiliation:

1. Department of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China

2. Beijing Hospital, Beijing, China

3. Department of Psychology, School of Education of Heilongjiang University, Harbin, Heilongjiang Province, China

4. The First Psychiatric Hospital of Harbin, Heilongjiang Province, China

5. Department of Medical Education Management, Harbin Medical University, Harbin, China

6. Department of Endocrinology, Peking Union Medical College Hospital, Beijing, China

Abstract

Background. Oxidative stress may be increased in a number of psychiatric disorders, including major depressive disorder (MDD). MDD has been shown to be related to insulin-like growth factor-1 (IGF-1) as well as to negative life events; exploring the interaction of IGF-1 polymorphisms and negative life events on the risk of MDD is needed. The aim of this study was to analyze the single and combined effects of IGF-1 polymorphisms (rs972936 and rs978458) and negative life events with MDD among Chinese population. Methods. 420 MDD patients (according to DSM-V) and 420 age- and gender-matched control subjects were recruited in a case-control study. Negative life events were assessed using standard rating scales. IGF-1 rs972936 and rs978458 were identified by sequencing. The chi-square ( χ 2 ) tests were performed to explore the association of negative life events and IGF-1 polymorphisms with MDD. Results. Our results found that the negative life events were associated with the risk of MDD ( P < 0.001 ; OR = 3.28 , 95% CI: 2.19-4.85). The genotypes of IGF-1 were associated with the risk of MDD ( P < 0.001 ); carrying the IGF-1 rs972936 C allele ( OR = 1.53 , 95% CI: 1.26-1.85) and rs978458 T allele ( OR = 1.92 , 95% CI: 1.58-2.34) had a higher risk of MDD. The combined effects between IGF-1 rs978458 and negative life events were associated with the risk of MDD ( P < 0.05 ; OR = 2.94 , 95% CI: 1.23-7.03), but IGF-1 rs972936 was not associated ( P > 0.05 ). Conclusions. Based on the oxidative stress hypothesis, we confirm that carrying IGF-1 rs972936 C allele and rs978458 T allele have a higher risk of MDD and the combined effects between IGF-1 rs978458 and negative life events were associated with the risk of MDD among Chinese population.

Funder

Natural Science Foundation of Heilongjiang Province

Publisher

Hindawi Limited

Subject

Cell Biology,Aging,General Medicine,Biochemistry

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