Diabetes Mellitus and Gastric Cancer: Correlation and Potential Mechanisms

Author:

Wang Li123ORCID,Zhang Zhe4ORCID

Affiliation:

1. Department of Emergency, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310052, China

2. Zhejiang Provincial Critical Research Center for Emergency Medicine Clinic, Hangzhou 310052, China

3. Key Laboratory of Diagnosis and Treatment of Severe Trauma and Burn of Zhejiang Province, Hangzhou 310052, China

4. Department of Emergency Medicine, The First People’s Hospital of Linping District, 311100, Hangzhou, Zhejiang, China

Abstract

This review summarizes the correlation between diabetes mellitus (DM) and gastric cancer (GC) from the perspectives of epidemiology, drug use, and potential mechanisms. The association between DM and GC is inconclusive, and the positive direction of the association reported in most published meta-analyses suggests that DM may be an independent risk factor for GC. Many clinical investigations have shown that people with DM and GC who undergo gastrectomy may have better glycemic control. The potential link between DM and GC may involve the interaction of multiple common risk factors, such as obesity, hyperglycemia and hyperinsulinemia, H. pylori infection, and the use of metformin. Although in vitro and in vivo data support that H. pylori infection status and metformin can influence GC risk in DM patients, there are conflicting results. Patient survival outcomes are influenced by multiple factors, so further research is needed to identify the patients who may benefit.

Funder

Hangzhou Science and Technology Development Plan Project

Publisher

Hindawi Limited

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Targeting PI3K/AKT/mTOR and MAPK Signaling Pathways in Gastric Cancer;International Journal of Molecular Sciences;2024-02-03

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