Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients

Author:

Chen Yu-Chen12,Xia Wenqing34,Feng Yuan5ORCID,Li Xiaowei3,Zhang Jian1,Feng Xu6,Wang Cong-Xiao1,Cai Yu1,Wang Jian78,Salvi Richard2ORCID,Teng Gao-Jun1

Affiliation:

1. Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China

2. Center for Hearing and Deafness, University at Buffalo, State University of New York, Buffalo, NY 14214, USA

3. Medical School, Southeast University, Nanjing 210009, China

4. Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, PA 19104, USA

5. Department of Radiology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006, China

6. Department of Otolaryngology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China

7. Department of Physiology, Southeast University, Nanjing 210009, China

8. School of Human Communication Disorders, Dalhousie University, Halifax, NS, Canada B3J 1Y6

Abstract

Purpose. Recent studies suggest that tinnitus may be due in part to aberrant callosal structure and interhemispheric interaction. To explore this hypothesis we use a novel method, voxel-mirrored homotopic connectivity (VMHC), to examine the resting-state interhemispheric functional connectivity and its relationships with clinical characteristics in chronic tinnitus patients. Materials and Methods. Twenty-eight chronic tinnitus patients with normal hearing thresholds and 30 age-, sex-, education-, and hearing threshold-matched healthy controls were included in this study and underwent the resting-state fMRI scanning. We computed the VMHC to analyze the interhemispheric functional coordination between homotopic points of the brain in both groups. Results. Compared to the controls, tinnitus patients showed significantly increased VMHC in the middle temporal gyrus, middle frontal gyrus, and superior occipital gyrus. In tinnitus patients, a positive correlation was found between tinnitus duration and VMHC of the uncus. Moreover, correlations between VMHC changes and tinnitus distress were observed in the transverse temporal gyrus, superior temporal pole, precentral gyrus, and calcarine cortex. Conclusions. These results show altered interhemispheric functional connectivity linked with specific tinnitus characteristics in chronic tinnitus patients, which may be implicated in the neuropathophysiology of tinnitus.

Funder

National Basic Research Program of China

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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