Low- and High-Tech Approaches to ControlPlasmodiumParasite Transmission byAnophelesMosquitoes

Abstract

Current efforts have proven inadequate to stop the transmission ofPlasmodiumparasites, and hence the spread of malaria, byAnophelesmosquitoes. Therefore, a novel arsenal of strategies for inhibitingPlasmodiuminfection of mosquitoes is urgently needed. In this paper, we summarize research on two approaches to malaria control, a low-tech strategy based on parasite inhibition by the mosquito's natural microflora, and a high-tech strategy using genetic modification of mosquitoes that renders them resistant to infection and discuss advantages and disadvantages for both approaches.