Affiliation:
1. Division of Rheumatology, Department of Internal Medicine, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China
Abstract
Macrophages are an important component of the human immune system and play a key role in the immune response, which can protect the body against infection and regulate the development of tissue inflammation. Some studies found that macrophages can produce extracellular traps (ETs) under various conditions of stimulation. ETs are web-like structures that consist of proteins and DNA. ETs are thought to immobilize and kill microorganisms, as well as play an important role in tissue damage, inflammatory progression, and autoimmune diseases. In this review, the structure, identification, mechanism, and research progress of macrophage extracellular traps (METs) in related diseases are reviewed.
Funder
National Natural Science Foundation of China
Subject
Immunology,General Medicine,Immunology and Allergy
Reference55 articles.
1. Neutrophil extracellular traps kill bacteria;V. Brinkmann;Science,2004
2. The immune system throws its traps: cells and their extracellular traps in disease and protection;F. Conceicao-Silva;Cell,2021
3. Multiple origins of extracellular DNA traps;E. Ramos-Martinez;Frontiers in Immunology,2021
4. Extracellular traps and macrophages: new roles for the versatile phagocyte;D. M. Boe;Journal of Leukocyte Biology,2015
5. Origins and diversity of macrophages in health and disease;G. Sreejit;Clinical & Translational Immunology,2020
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