Association of ERCC1 rs11615 Polymorphism with the Risk of Cervical Cancer Especially in Chinese Populations: A Meta-Analysis

Abstract

Abnormalities of the ERCC1 gene can affect DNA repair pathways, thereby having a vital effect on genomic stability. A growing amount of case-control studies have focused on making an investigation of the association between ERCC1 rs11615 polymorphism and cervical cancer susceptibility. However, the controversial results have raised concerns. To draw a more accurate conclusion, six studies were elaborately selected from the electronic databases for this meta-analysis, with 753 cervical cancer cases and 851 healthy controls. We applied pooled ORs combined with 95% CIs to test the potential associations. Significant associations were revealed in Chinese populations (T vs C: $\text{OR}=1.557$ and $95\%\text{CI}=1.234–1.966$ ; TT vs CC: $\text{OR}=3.175$ and $95\%\text{CI}=1.754–5.748$ ; TT/CT vs CC: $\text{OR}=1.512$ and $95\%\text{CI}=1.126–\mathrm{2,031}$ ; and TT vs CT/CC: $\text{OR}=2.836$ and $95\%\text{CI}=1.592–5.051$ ). Even when the studies deviating from HWE were excluded, an increased cervical cancer susceptibility was observed in Chinese. These results disclose that there is an obvious correlation between the risk of cervical cancer and ERCC1 rs11615 polymorphism, especially in Chinese populations, and the T variant is the risky one. Also, our findings need further studies to validate.