Affiliation:
1. Department of Urology, Zhongshan Hospital, Fudan University, China
2. Department of Urology, Changhai Hospital, Naval Medical University, China
Abstract
Histone demethylase JMJD4 is a burgeoning tumor marker, which has been proven to be associated with colon cancer, but the role it plays in kidney cancer has not yet been investigated. In the present study, we evaluated whether JMJD4 can be a prognostic marker of patients with clear cell renal cell carcinoma (ccRCC) using data from public platform and in vitro experiments. Our results revealed that the expression of JMJD4 is higher in cancerous tissue than in normal tissues (
). High expression of JMJD4 is associated with a poor overall survival (OS) of ccRCC as compared with low expression of JMJD4 (
). JMJD4 showed significant relevance with M stage (
), gender (
), OS (0.018), disease-specific survival (DSS) (0.007), and percussion free interval (PFI) (0.041). Univariate and multivariate Cox analyses demonstrated that high JMJD4 expression had independent predictive value for OS in ccRCC patients (
,
, and
). Besides, in vitro experiments confirmed that high expression of JMJD4 can significantly promote the invasion ability (
), cloning ability (
), and proliferation (
) of renal cell carcinoma. In summary, high JMJD4 expression may be a prognostic marker in patients with kidney cancer.
Funder
Shanghai Science and Technology Development Foundation
Subject
Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. JMJD family proteins in cancer and inflammation;Signal Transduction and Targeted Therapy;2022-09-01