Transformation of Two Cases of Lung Adenocarcinoma into Pulmonary Sarcomatoid Carcinoma following Treatment

Author:

Yang Zhenyu1ORCID,Shen Yinfang2,Jiang Junhong1,Liu Ziyi1,Mu Chuanyong1ORCID

Affiliation:

1. Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, China

2. Department of Pathology, First Affiliated Hospital of Soochow University, Suzhou, China

Abstract

Accumulating evidence shows that histologic transformation is involved in the drug resistance of lung cancer. Moreover, it is common for lung adenocarcinoma to transform into small-cell lung cancer or squamous cell carcinoma; however, clinical cases with sarcomatoid transformation have been rarely reported. Thus, both the diagnosis and treatment of lung adenocarcinoma with sarcomatoid transformation remain difficult. Here, we discuss two patients with lung adenocarcinoma with sarcomatoid transformation—analyzing the diagnosis, clinical features, immunohistochemical characteristics, therapy, and prognosis—with the hope that this report will be used as a reference for future treatment of these patients.

Funder

Science and Technology Development Projects of Suzhou

Publisher

Hindawi Limited

Subject

Pulmonary and Respiratory Medicine

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