TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway-Reference-Cited by-全球学者库

TNFAIP6 Promotes Gastric Carcinoma Cell Invasion via Upregulating PTX3 and Activating the Wnt/β-Catenin Signaling Pathway

Published:2022-07-06 Issue: Volume:2022 Page:1-9
ISSN:1555-4317
Container-title:Contrast Media & Molecular Imaging
language:en
Short-container-title:Contrast Media & Molecular Imaging

Author:

Cui Hongquan¹,Zhang Ling¹,Chen Bin¹,Zhang Fengchun¹,Xu Haiyan¹,Ma Guixiang²,Cao Longnv¹,Wang Miao²^ORCID

Affiliation:

1. Oncology Department Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou 215127, China

2. Oncology Department, Siyang Hospital, Suqian 223798, China

Abstract

Tumor metastasis is a fundamental cause of the poor prognosis of gastric carcinoma (GC). In order to study the problems affecting metastasis and recurrence of gastric cancer, the paper expose that TNF alpha induced protein 6 (TNFAIP6) is aberrantly overexpressed in GC, and patients with high-TNFAIP6 levels exhibited inferior overall survival. Mechanistically, overexpression of TNFAIP6 raised β-catenin ectopic nuclear distribution and activated the Wnt/β-catenin signal pathway. The experimental results show that TNFAIP6 facilitates the aggressive potential of GC cells through modulating PTX3 expression.

Funder

The Third Level Training Object of Suqian Second Phase “Thousand Top Talent Training Project”

Publisher

Hindawi Limited

Subject

Radiology, Nuclear Medicine and imaging

Link

http://downloads.hindawi.com/journals/cmmi/2022/5697034.pdf

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