Spontaneous Remission in an Older Patient with RelapsedFLT3ITD Mutant AML

Author:

Vachhani Pankit1ORCID,Mendler Jason H.2,Evans Andrew3,Deeb George4,Starostik Petr5,Wallace Paul K.6,Wang Eunice S.1

Affiliation:

1. Leukemia Service, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA

2. Department of Medicine, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA

3. Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA

4. Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA

5. Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA

6. Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA

Abstract

Spontaneous remission (SR) of acute myeloid leukemia (AML) is a very rare phenomenon. AML characterized byFLT3internal tandem duplication (FLT3ITD) is typically associated with an aggressive clinical course with rapid progression, relapse, and short overall survival in the absence of transplantation. We report here the first case of SR ofFLT3ITD mutant AML in the literature. Our patient was an elderly woman with relapsedNPM1andFLT3ITD mutant AML whose disease underwent SR for a brief duration without precipitating cause. We review the potential immune mechanisms underlying SR in AML and discuss the implications for novel immunotherapeutic approaches forFLT3mutant AML.

Publisher

Hindawi Limited

Subject

Cell Biology,Developmental Biology,Embryology,Anatomy

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