Review of Atypical Organometallic Compounds as Antimalarial Drugs

Author:

Kwofie Samuel K.123,Broni Emmanuel1ORCID,Dankwa Bismark4ORCID,Enninful Kweku S.4ORCID,Teye Joshua1,Davidson Cedar R.5,Nimely Josephine B.5,Chioma Orizu J.6,Kempaiah Prakasha3ORCID,Rathi Brijesh37ORCID,Miller Whelton A.138ORCID

Affiliation:

1. Department of Biomedical Engineering, School of Engineering Sciences, College of Basic and Applied Sciences, University of Ghana, PMB LG 77, Legon, Accra, Ghana

2. West African Center for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Legon, Accra, Ghana

3. Department of Medicine, Loyola University Chicago, Loyola University Medical Center, Maywood, IL 60153, USA

4. Department of Parasitology, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences (CHS), University of Ghana, Legon, Accra, Ghana

5. Department of Biology, Lincoln University, Chester County, PA 19352, USA

6. Department of Chemistry, Physics & Engineering, Lincoln University, Chester County, PA 19352, USA

7. Laboratory for Translational Chemistry and Drug Discovery, Department of Chemistry, Hansraj College University Enclave, University of Delhi, Delhi 110007, India

8. Department of Chemical and Biomolecular Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA

Abstract

Organometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. Ferroquine, which was developed due to the emergence of chloroquine resistance, is currently the most advanced organometallic antimalarial drug and has paved the way for the development of new organometallic antimalarials. In this review, a general overview of organometallic antimalarial compounds and their antimalarial activity in comparison to purely organic antimalarials are presented. Furthermore, recent developments in the field are discussed, and future applications of this emerging class of therapeutics in antimalarial drug discovery are suggested.

Funder

National Science Foundation

Publisher

Hindawi Limited

Subject

General Chemistry

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