The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m6A-Reference-Cited by-同舟云学术

The Role of RNA Methylation in Regulating Stem Cell Fate and Function-Focus on m6A

Published:2021-10-28 Issue: Volume:2021 Page:1-13
ISSN:1687-9678
Container-title:Stem Cells International
language:en
Short-container-title:Stem Cells International

Author:

Sun Weiwei¹^ORCID,Zhang Bin²,Bie Qingli²,Ma Na¹,Liu Na¹,Shao Zewei¹^ORCID

Affiliation:

1. Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, Shandong, China

2. Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong, China

Abstract

The biological role of RNA methylation in stem cells has attracted increasing attention. Recent studies have demonstrated that RNA methylation plays a crucial role in self-renewal, differentiation, and tumorigenicity of stem cells. In this review, we focus on the biological role of RNA methylation modifications including N6-methyladenosine, 5-methylcytosine, and uridylation in embryonic stem cells, adult stem cells, induced pluripotent stem cells, and cancer stem cells, so as to provide new insights into the potential innovative treatments of cancer or other complex diseases.

Funder

Jining Medical University

Publisher

Hindawi Limited

Subject

Cell Biology,Molecular Biology

Link

http://downloads.hindawi.com/journals/sci/2021/8874360.pdf

Reference102 articles.

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2. Emerging Roles of RNA Modification: m 6 A and U-Tail

3. The metabolic programming of stem cells