Affiliation:
1. Department of Cell Biology, University of Alberta, Edmonton, AB, Canada T6G 2H7
Abstract
Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog ofβ-catenin. As a component of both the adherens junctions and desmosomes, plakoglobin plays a pivotal role in the regulation of cell-cell adhesion. Furthermore, similar toβ-catenin, plakoglobin is capable of participating in cell signaling. However, unlikeβ-catenin that has well-documented oncogenic potential through its involvement in the Wnt signaling pathway, plakoglobin generally acts as a tumor/metastasis suppressor. The exact roles that plakoglobin plays during tumorigenesis and metastasis are not clear; however, recent evidence suggests that it may regulate gene expression, cell proliferation, apoptosis, invasion, and migration. In this paper, we describe plakoglobin, its discovery and characterization, its role in regulating cell-cell adhesion, and its signaling capabilities in regulation of tumorigenesis and metastasis.
Cited by
59 articles.
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