Rituximab May Have Positive Effect on Refractory Nephrotic Syndrome: A Meta-Analysis of Randomized Trials

Abstract

Purpose. This study was aimed at demonstrating the role of rituximab (RTX) on the influence of nephrotic syndrome (NS) and on urinary protein which was not significant. Methods. The clinical randomized controlled trials were performed by eight databases. Meanwhile, the confidence interval (CI) of either relative risk or mean difference was set to 95%. Besides, the heterogeneity of the research results is tested by $I^2$ . Results. A total of 1658 references were found using the search method. This meta-analysis will be done by the ultimately eight different studies. Each study is described as random controlled trial. According to these eight studies, the remission of test group and control group was quite higher (OR: 1.60; 95% Cl: 1.17, 2.20; $P<0.01$ ) than the control group, serum albumin (SMD: 4.19; 95% Cl: 1.49, 6.89; $P<0.01$ ), and urine protein (SMD: 0.79; 95% Cl: -0.64, 2.22; $P=0.28$ ). Despite the fact that the remission rate’s funnel plot was asymmetrically distributed, Egger’s test and Begg’s test revealed no probable publish bias. Conclusion. The results of this study suggest that rituximab (RTX) may be effective in RNS, as evidenced by remission rates and serum albumin. However, the effect on urinary protein was not significant. The clear evidence is missing in this literature. Therefore, large sample, multicenter, low risk of bias clinical studies, as well as basic medical research, is needed.