Effect of Perioperative Dexmedetomidine Anesthesia on Prognosis of Elderly Patients with Gastrointestinal Tumor Surgery

Abstract

It was to investigate the influence of perioperative dexmedetomidine (DEX) anesthesia on the prognosis of elderly patients with gastrointestinal tumor (GIT) surgery. 90 patients who underwent laparoscopic radical gastrectomy for GIT were included. They were randomly divided into the experimental group (45 cases) with DEX+general anesthesia, and the control group (45 cases) with epidural anesthesia+general anesthesia. The indicators after surgery were compared between the two groups. The mean arterial pressure (MAP) was $74.8\pm 3.5$  mmHg and the heart rate (HR) was $52.7\pm 8.2$ beats/min-1 in the experimental group, significantly lower than those of the control group ( $P<0.05$ ). The Visual Analog Scale (VAS) scores of both groups decreased greatly associated to those before surgery ( $P<0.05$ ). The levels of cortisol (COR) and immune adhesion inhibitor (FEIR) in the experimental group were significantly dissimilar from those in the control group ( $P<0.05$ ). The tumor necrosis factor-alpha (TNF-α) was $96.4\pm 21.8$  ng/L in the experimental group, observably lower than that in the control group ( $P<0.05$ ). The postoperative diamine oxidase (DAO) and D-lactate (D-lac) were $62.4\pm 9.3$  μmol/mL and $33.8\pm 7.2$  ng/L, respectively, in the experimental group, much lower than those in the control group ( $P<0.05$ ). There were also significant differences in the initial recovery of bowel sounds, defecation, and total length of hospital stay (LOHS) between the groups ( $P<0.05$ ). DEX anesthesia had ideal sedative and analgesic effects, improving the prognosis of patients during surgery, and shortening the LOHS. Thus, it deserved a clinical application value.