A Review on JC Virus Infection in Kidney Transplant Recipients

Author:

Delbue Serena1,Ferraresso Mariano23,Ghio Luciana4,Carloni Camilla5,Carluccio Silvia5,Belingheri Mirco4,Edefonti Alberto4,Ferrante Pasquale56

Affiliation:

1. Laboratory of Translational Research, Health Science Foundation “Ettore Sansavini”, Corso Garibaldi 11, 48022 Lugo, Italy

2. Department of General and Vascular Surgery, St. Joseph Hospital, Via San Vittore 12, 20122 Milan, Italy

3. Department of Clinical Sciences and Community Health, University of Milan, Via Francesco Sforza 35, 20122 Milan, Italy

4. Pediatric Nephrology and Dialysis Unit, IRCCS Ca’ Granda Foundation “Ospedale Maggiore Policlinico”, Via Francesco Sforza 35, 20122 Milan, Italy

5. Laboratory of Translational Research, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Pascal 36, 20133 Milan, Italy

6. Clinical Institute “Città Studi”, Via Ampere 47, 20133 Milan, Italy

Abstract

The polyomavirus (PyV), JC virus (JCV), is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, known as progressive multifocal leukoencephalopathy (PML). Although the reactivation of another human PyV, BK virus (BKV), is relatively common and its association with the polyomavirus associated nephropathy (PyVAN) following renal transplantation is proven, JCV replication and its impact on graft function and survival are less well studied. Here we describe the biology of JCV and its pathological features and we review the literature regarding the JCV infection analyzed in the setting of transplantations.

Publisher

Hindawi Limited

Subject

General Medicine,Immunology,Immunology and Allergy

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