BAG3 and HIF-1αCoexpression Detected by Immunohistochemistry Correlated with Prognosis in Hepatocellular Carcinoma after Liver Transplantation

Abstract

Objective. The objective is to determine the effects of BAG3 and HIF-1αexpression on the prognosis of HCC patients after liver transplantation.Methods. Samples from 31 patients with HCC receiving liver transplantation were collected for this study. The immunohistochemistry was used to detect the expression of BAG3 and HIF-1αof HCC samples.Results. According to the immunohistochemistry results, BAG3 and HIF-1αstaining were significantly associated with tumor TNM stage (P=0.004,P=0.012). A significant association between high BAG3/HIF-1αlevels and a shorter overall survival was detected, so as the combined BAG3 and HIF-1αanalysis.Conclusion. The results suggested that the expression level of BAG3 and HIF-1αis efficient prognostic parameters in patients with HCC after liver transplantation.