ZEB1 Expression in Endometrial Biopsy Predicts Lymph Node Metastases in Patient with Endometrial Cancer

Author:

Feng Gang1,Wang Xiangming2,Cao Xiaozhi3,Shen Lijuan4,Zhu Jiansheng5

Affiliation:

1. Clinical Genetics Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China

2. Department of Pathology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China

3. Department of Pathology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, China

4. Department of Pathology, Wuhu Hospital of Traditional Chinese Medicine, Wuhu, Anhui 241001, China

5. Molecular Pathological Laboratory, Maternal and Child Health Hospital of Anhui Province, Anhui Medical University, Hefei, Anhui 230001, China

Abstract

Purpose. The purpose of this study was to analyze the expression of zinc-finger E-box-binding homeobox 1 (ZEB1) in endometrial biopsy and its correlation with preoperative characteristics, including lymph node metastases in patient with endometrial cancer.Methods. Using quantitative RT-PCR, ZEB1 expressions in endometrial biopsy from 452 patients were measured. The relationship between ZEB1 expression and preoperative characteristics was analyzed.Results. ZEB1 expressions were significantly associated with subtype, grade, myometrial invasion, and lymph node metastases. Lymph node metastases could be identified with a sensitivity of 57.8% at specificity of 74.1% by ZEB1 expression in endometrial biopsy. Based on combination of preoperative characteristics and ZEB1 expression, lymph node metastases could be identified with a sensitivity of 62.1% at specificity of 96.2% prior to hysterectomy.Conclusion. ZEB1 expression in endometrial biopsy could help physicians to better predict the lymph node metastasis in patients with endometrial cancer prior to hysterectomy.

Funder

The First Affiliated Hospital of Wannan Medical College

Publisher

Hindawi Limited

Subject

Biochemistry (medical),Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

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