Plasma miR-208b and miR-499: Potential Biomarkers for Severity of Coronary Artery Disease

Author:

Wang Wei1,Li Tai2,Gao Lei3,Li Yang3,Sun Ying1,Yao Heng-Chen1ORCID

Affiliation:

1. Department of Cardiology, Liaocheng People’s Hospital Affiliated to Shandong University and Clinical School of Shandong First Medical University, Liaocheng 252000, China

2. Department of Nursing, Liaocheng Vocational and Technical College, Liaocheng 252000, China

3. Zhong Yuan Academy of Biological Medicine, Liaocheng People’s Hospital, Shandong University, Liaocheng, China

Abstract

Aims. MicroRNAs (miRNAs) are associated with the pathogenesis of coronary artery disease (CAD). The objective of this study is to explore plasma levels of miR-208b and miR-499 in CAD and analyze its association with the severity of CAD. Materials and Methods. 195 consecutive CAD patients who underwent coronary angiography were enrolled in this study. Severity of coronary lesions was evaluated by the synergy between percutaneous coronary intervention with taxus and cardiac surgery score (SYNTAX) score (SS). Plasma levels of miR-208b and miR-499 were assessed by quantitative real-time polymerase chain reaction (qRT-PCR). The relationship between miR-208b and miR-499 and SS was analyzed. Results. The qRT-PCR results showed that plasma levels of miR-208b and miR-499 in SS>32 (high SS) group was higher than those in low (SS22) and intermediate (22<SS32) groups. Meanwhile, plasma miR-208b and miR-499 levels were significantly positive correlated with the SS (Spearman’s r=0.535 and r=0.407, respectively; both p<0.001). Multivariate logistic analysis results showed that miR-208b (odds ratio [OR]: 2.069; 95% confidence interval [CI]: 1.351-3.167; p=0.001) and miR-499 (OR: 1.652; 95% CI: 1.222-2.233; p=0.001) were independent predictors of high SS. In receiver operating characteristic curve, the area under the curve of miR-208b and miR-499 in prediction of high SS was 0.775 and 0.713, respectively. Conclusions. Higher plasma levels of miR-208b and miR-499 were positively associated with the severity of CAD, and plasma miR-208b and miR-499 can act as potential biomarkers for estimating the severity of CAD.

Funder

Science and Technology Development Plan Project of Shandong Province

Publisher

Hindawi Limited

Subject

Biochemistry, medical,Clinical Biochemistry,Genetics,Molecular Biology,General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3