KPNA3Variation Is Associated with Schizophrenia, Major Depression, Opiate Dependence and Alcohol Dependence

Abstract

KPNA3is a gene that has been linked to schizophrenia susceptibility. In this study we investigated the possible association betweenKPNA3variation and schizophrenia. To investigate a wider role ofKPNA3across psychiatric disorders we also analysed major depression, PTSD, nicotine dependent, alcohol dependent and opiate dependent cohorts. Using a haplotype block-based gene-tagging approach we genotyped sixKPNA3single nucleotide polymorphisms (SNPs) in 157 schizophrenia patients, 121 post-traumatic stress disorder patients, 120 opiate dependent patients, 231 alcohol dependent patients, 147 nicotine dependent patients and 266 major depression patients. One SNP rs2273816 was found to be significantly associated with schizophrenia, opiate dependence and alcohol dependence at the genotype and allele level. Major depression was also associated with rs2273816 but only at the allele level. Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders.