The Therapeutic Potential of Wogonin Observed in Preclinical Studies-Reference-Cited by-同舟云学术

The Therapeutic Potential of Wogonin Observed in Preclinical Studies

Published:2021-06-15 Issue: Volume:2021 Page:1-9
ISSN:1741-4288
Container-title:Evidence-Based Complementary and Alternative Medicine
language:en
Short-container-title:Evidence-Based Complementary and Alternative Medicine

Author:

Sharifi-Rad Javad¹²^ORCID,Herrera-Bravo Jesús³⁴,Salazar Luis A.⁴,Shaheen Shabnum⁵,Abdulmajid Ayatollahi Seyed¹⁶⁷,Kobarfard Farzad¹⁸,Imran Muhammad⁹,Imran Ali¹⁰,Custódio Luísa¹¹,Dolores López María¹²,Schoebitz Mauricio¹³,Martorell Miquel¹⁴¹⁵^ORCID,Kumar Manoj¹⁶^ORCID,Ansar Rasul Suleria Hafiz¹⁷,Cho William C.¹⁸^ORCID

Affiliation:

1. Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2. Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador

3. Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Santiago, Chile

4. Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco 4811230, Chile

5. Department of Plant Sciences, LCWU, Lahore 54000, Pakistan

6. Department of Pharmacognosy and Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

7. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

8. Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

9. University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Lahore, Pakistan

10. Department of Food Science, Nutrition & Home Economics, Institute of Home and Food Sciences Government College University, Faisalabad, Pakistan

11. Centre of Marine Sciences, University of Algarve, Faculty of Sciences and Technology, Building 7, Campus of Gambelas, Faro 8005-139, Portugal

12. Department of Plant Production, Faculty of Agronomy, Universidad de Concepción, Avenida Vicente Mendez, 595, Chillán 3812120, Chile

13. Departamento de Suelos y Recursos Naturales, Facultad de Agronomía, Universidad de Concepción, Concepción, Chile

14. Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción 4070386, Chile

15. Unidad de Desarrollo Tecnológico, Universidad de Concepción UDT, Concepción 4070386, Chile

16. Chemical and Biochemical Processing Division, ICAR–Central Institute for Research on Cotton Technology, Mumbai 400019, India

17. Department of Agriculture and Food Systems, The University of Melbourne, Melbourne 3010, Australia

18. Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong

Abstract

Wogonin is a flavonoid found in different plants such as roots of Scutellaria baicalensis Georgi distributed mainly in Asia and Europe. Dried root extracts of S. baicalensis with high content of wogonin, popularly known as “Huang-Qin” or Chinese or baical skullcap, have been used for long time in traditional Chinese medicine. Several health benefits are attributed to wogonin and derivatives showing anti-inflammatory, antiviral, anticancer, and antioxidant effects and more recently antineurodegenerative properties. Preclinical pharmacological activities of wogonin against diverse types of cancer such as breast, colorectal, and human gastric cancer will be presented in this review. In addition, studies on oxidative stress and bioavailability of wogonin will be discussed together with antineurodegenerative potential with special focus on Alzheimer’s disease. Outcomes extracted from the last preclinical studies related to therapeutic applications of wogonin will be commented and updated in this review. The scientific evidence collected in this review aims to encourage transfer of the preclinical evidence of wogonin to new clinical studies.

Publisher

Hindawi Limited

Subject

Complementary and alternative medicine

Link

http://downloads.hindawi.com/journals/ecam/2021/9935451.pdf

Reference77 articles.

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