HuR Promotes the Progression of Gastric Cancer through Mediating CDC5L Expression

Abstract

Background and Objectives. Gastric cancer (GC) is one of the common gastrointestinal tumors and the third in the mortality rate among tumors. Studies have shown that the human antigen receptor (HuR) is associated with the malignant degree of GC. Methods. We performed qRT-PCR, cell cycle assay, cell migration, and mouse transplantation model analysis in our experiments. It has been clarified that HuR and microRNAs (miRNAs) have important interplays in the regulation of tumor progression. Results. This study found microRNA-133b (miR-133b), as a HuR-sponged miRNA in GC cells. Downregulation of HuR can promote the expression of miR-133b and further affect the downstream cyclin CDC5L. The expressions of miR-133b were slightly lower in GC tissues than adjacent normal tissues. Conclusion. Our studies suggest that HuR and miR-133b are involved in the development and pathological process of GC cells.