1. Leeds Institute of Rheumatic and Musculoskeletal Disease, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Trust Teaching Hospital, Leeds LS9 7TF, UK
2. Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK
3. Centre for Biochemical Pharmacology Research Unit, William Harvey Research Institute, Barts and London, Queen Mary’s School of Medicine and Dentistry, University of London, Charterhouse Square, London EC1M 6BQ, UK
4. Department of Physiology, Anatomy and Genetics, University of Oxford, Le Gros Clark Building, Oxford OX1 3QX, UK
5. University of Exeter Medical School, St. Luke’s Campus, Exeter, Devon EX1 2LU, UK