A Randomized Controlled Trial of the Effect of 0.01% Atropine Eye Drops Combined with Auricular Acupoint Stimulation on Myopia Progression

Author:

Kong Xie-He1ORCID,Zhao Yue1ORCID,Chen Zhi234ORCID,Zeng Li234ORCID,Han Rong5ORCID,Dong Xiao-Qing5ORCID,Guo Xiao-Cong5ORCID,Shi Zheng1ORCID,Yang Guang1ORCID,Yang Yan-Ting1ORCID,Zhang Dan1ORCID,Zhou Xing-Tao234ORCID,Ma Xiao-Peng1ORCID

Affiliation:

1. Shanghai Research Institute of Acupuncture and Meridian, Shanghai 200030, China

2. Department of Ophthalmology and Visual Science, Eye and ENT Hospital of Fudan University, Shanghai 200031, China

3. NHC Key Laboratory of Myopia, Fudan University, Shanghai 200031, China

4. Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai 200031, China

5. Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China

Abstract

Background. Use of 0.01% atropine eye drops (0.01% A) is one of the most common treatments for myopia control for children in Asia. Auricular acupoint stimulation (AAS) was reported to enhance the effect of higher-concentration atropine (0.25%, 0.125%) on myopia control. This study was designed to compare the effect of 0.01% A combined with AAS and 0.01% A alone on myopia progression and choroidal thickness in children. Methods. A total of 104 children were stratified by age and randomly assigned at 1 : 1 to receive 0.01% A or 0.01% A + AAS treatment for 6 months. Repeated measurements of cycloplegic spherical equivalent (SE) autorefraction, axial length (AL), and choroidal thickness were performed at baseline, 1 month, 3 months, and 6 months. Results. The adjusted mean SE change over the 6 months was −0.38 ± 0.04 D in the 0.01% A group (n = 50) and −0.25 ± 0.04 D in the 0.01% A + AAS group (n = 50), demonstrating a significant between-group difference ( P  = 0.02). There was no statistically significant difference in the change of AL and choroidal thickness between the two groups (both P  > 0.05). Conclusions. Adjunctive AAS compared with 0.01% A monotherapy slowed myopic progression in Chinese children by a statistically small amount, but had no effect on axial elongation and choroidal thickness during this 6-month observation. The trial is registered with ChiCTR1900021316.

Funder

Shanghai Municipal Health Commission

Publisher

Hindawi Limited

Subject

Ophthalmology

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