Two tagSNPs rs352493 and rs3760908 withinSIRT6Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population

Abstract

SIRT6has been demonstrated to exert protective effects on endothelial cells and is closely associated with lipid metabolism, glucose metabolism, and obesity, indicating an important role in the pathogenesis and progression of coronary artery disease (CAD). Nonetheless, the biological significance ofSIRT6variants on CAD is far to be elucidated. Here we aimed to investigate the influence ofSIRT6polymorphisms on individual susceptibility and severity of CAD. Multivariate logistic regression analysis exhibited no significant association between these five polymorphisms and CAD risk in the genotype and allele frequencies. However, we found that the rs352493 polymorphism inSIRT6exhibited a significant effect on the severity of CAD; C allele (χ2= 7.793, adjustedP=0.013) and the combined CC/CT genotypes (χ2= 5.609, adjustedP=0.031) presented the greater CAD severity. In addition, A allele (χ2= 5.208, adjustedP=0.046) and AA (χ2= 4.842, adjustedP=0.054) of rs3760908 were also associated with greater CAD severity in Chinese subjects. Our data provided the first evidence thatSIRT6tagSNPs rs352493 and rs3760908 play significant roles in the severity of CAD in Chinese Han subjects, which might be useful predictors of the severity of CAD.