miR-183-5p Aggravates Breast Cancer Development via Mediation of RGS2-Reference-Cited by-同舟云学术

miR-183-5p Aggravates Breast Cancer Development via Mediation of RGS2

Published:2021-11-20 Issue: Volume:2021 Page:1-9
ISSN:1748-6718
Container-title:Computational and Mathematical Methods in Medicine
language:en
Short-container-title:Computational and Mathematical Methods in Medicine

Author:

Wu Chihua¹^ORCID,Tuo Youlin²,Hu Gang²³^ORCID,Luo Jing²³^ORCID

Affiliation:

1. Department of Breast Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu 610072, China

2. Department of Breast Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China

3. Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China

Abstract

This study mainly explores how miR-183-5p pertains to breast cancer (BC) development. Functional assays were employed to test impacts of miR-183-5p in this cancer. Targeting between RGS2 and miR-183-5p was examined with dual-luciferase assay, and how their interaction pertains to cancer progression was further unraveled. miR-183-5p level was noticeably high in cancer tissue/cells. Overexpressing miR-183-5p could remarkably deteriorate cancer progression. The regulatory gene RGS2 levels was markedly low in BC, and two genes we researched were negatively correlated. It was uncovered by rescue assay that miR-183-5p/RGS2 axis mediated tumor-relevant behaviors in BC. Altogether, miR-183-5p aggravates BC development via mediation of RGS2. miR-183-5p supplies a promising target for BC therapy.

Funder

Department of Science and Technology of Sichuan Province

Publisher

Hindawi Limited

Subject

Applied Mathematics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Modeling and Simulation,General Medicine

Link

http://downloads.hindawi.com/journals/cmmm/2021/9664195.pdf

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