The Function of circRNA-0047604 in Regulating the Tumor Suppressor Gene DACH1 in Breast Cancer

Author:

Zhao Bingkun123,Zhou Rong1,Ji Changle2,Liu Diya2,Wu Tianqi2,Xu Hui2,Lan Dongmei4,Yao Chao4,Xu Yuanzhi1ORCID,Fang Lin12ORCID

Affiliation:

1. Department of Stomatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China

2. Department of Breast and Thyroid Surgery, Shanghai Tenth People’s Hospital, Shanghai 200072, China

3. Department of Plastic Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China

4. Medical College of Anhui University of Science and Technology, Huainan, Anhui 232000, China

Abstract

Breast cancer is the most common cancer among females. Dachshund Homolog 1 (DACH1) gene is regarded as an important tumor suppressor gene in breast cancer which plays an important regulatory role in the development disease progression, particularly in carcinomas. Circular RNAs (circRNAs) and microRNA (miRNA), regarded as a novel group of noncoding RNAs, are always involved in regulating gene expression. In this work, hsa_circ_0047604 expressed lower in breast cancer tissue and played the role of sponge of miR-548o. By this way, hsa_circ_0047604 could upregulate DACH1 to inhibit breast cancer. In conclusion, this study revealed that hsa_circ_0047604 acted as a tumor suppressor and regulated breast cancer progression via hsa_circ_0047604–miR-548o–DACH1 axis, which might provide a therapeutic method for breast cancer.

Funder

Shanghai Municipal Health Commission

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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