Anticancer and Anti-Inflammatory Mechanisms of NOSH-Aspirin and Its Biological Effects

Author:

Zhou Jun1ORCID,Zeng Weihong1,Zeng Ying12,Li Yukun1,Xiao Zheng1,Zou Juan1,Peng Lijun13,Xia Jiliang1ORCID,Zeng Xi1ORCID

Affiliation:

1. Hunan Province Key Laboratory of Tumor Cellular & Molecular Pathology, Cancer Research Institute, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China

2. School of Nursing, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China

3. Department of Spine Surgery, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China

Abstract

NOSH-Aspirin, which is generated from NO, H2S, and aspirin, affects a variety of essential pathophysiological processes, including anti-inflammatory, analgesic, antipyretic, antiplatelet, and anticancer properties. Although many people acknowledge the biological significance of NOSH-Aspirin and its therapeutic effects, the mechanism of action of NOSH-Aspirin and its regulation of tissue levels remains obscure. This is in part due to its chemical and physical features, which make processing and analysis difficult. This review focuses on the biological effects of NOSH-Aspirin and provides a comprehensive analysis to elucidate the mechanism underlying its disease-protective benefits.

Funder

Education Department of Hunan Province

Publisher

Hindawi Limited

Subject

Applied Mathematics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,Modeling and Simulation,General Medicine

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