Scorpion-Derived Antiviral Peptides with a Special Focus on Medically Important Viruses: An Update

Author:

El Hidan Moulay Abdelmonaim1ORCID,Laaradia Mehdi Ait2ORCID,El Hiba Omar3ORCID,Draoui Ahmed4ORCID,Aimrane Abdelmohcine35ORCID,Kahime Kholoud6ORCID

Affiliation:

1. Laboratory of Biotechnology and Valorization of Natural Resources, Faculty of Applied Sciences, Ibn Zohr University, Agadir, Morocco

2. Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech, Morocco

3. Nutritional Physiopathology Team, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco

4. Laboratory of Clinical and Experimental Neurosciences and Environment, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Morocco

5. Metabolic Platform, Biochemistry Laboratory, Faculty of Medicine, Cadi Ayad University, Marrakech, Morocco

6. SAEDD Laboratory, School of Technology Essaouira, Cadi Ayyad University of Marrakesh, Morocco

Abstract

The global burden of viral infection, especially the current pandemics of SARS-CoV-2, HIV/AIDS, and hepatitis, is a very risky one. Additionally, HCV expresses the necessity for antiviral therapeutic elements. Venoms are known to contain an array of bioactive peptides that are commonly used in the treatment of various medical issues. Several peptides isolated from scorpion venom have recently been proven to possess an antiviral activity against several viral families. The aim of this review is to provide an up-to-date overview of scorpion antiviral peptides and to discuss their modes of action and potential biomedical application against different viruses.

Funder

Centre National pour la Recherche Scientifique et Technique

Publisher

Hindawi Limited

Subject

General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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