Impactul consumului de canabis asupra semnelor neurologice minore la pacienţii cu schizofrenie

Abstract

The impact of cannabis use on neurological soft signs (NSS) in patients with schizophrenia is a topic of growing interest. This narrative review aims to provide an overview of the current understanding of this relationship. The PubMed database was used to identify relevant articles, and the initial search yielded a total of 144 publications. By using automation tools, 137 records were removed, and seven remaining studies were further reviewed in full-text.  Results. The findings suggest that, although the use of cannabis decreases the global expression of NSS, heavy cannabis use is associated with higher levels of NSS in sensorimotor subdomains related to complex motor tasks. Furthermore, neuroimaging studies have revealed alterations in brain regions involved in sensorimotor execution and control in individuals with heavy cannabis use. These findings support the hypothesis that cannabis, through its effects on the sensorimotor system, can impair neurological functioning and increase the positive symptoms of schizophrenia. In conclusion, this narrative review highlights the complex relationship between cannabis use, neurological soft signs and schizophrenia. Understanding the impact of cannabis on NSS in patients with schizophrenia is crucial for developing targeted interventions and for optimizing treatment outcomes. Further research, including longitudinal studies and meta-analyses, is warranted to enhance our understanding of this important area.