Author:
Vardavas C.I.,Hohmann C.,Patelarou E.,Martinez D.,Henderson A.J.,Granell R.,Sunyer J.,Torrent M.,Fantini M.P.,Gori D.,Annesi-Maesano I.,Slama R.,Duijts L.,de Jongste J.C.,Aurrekoetxea J.J.,Basterrechea M.,Morales E.,Ballester F.,Murcia M.,Thijs C.,Mommers M.,Kuehni C.E.,Gaillard E.A.,Tischer C.,Heinrich J.,Pizzi C.,Zugna D.,Gehring U.,Wijga A.,Chatzi L.,Vassilaki M.,Bergström A.,Eller E.,Lau S.,Keil T.,Nieuwenhuijsen M.,Kogevinas M.
Abstract
Maternal smoking during pregnancy increases childhood asthma risk, but health effects in children of nonsmoking mothers passively exposed to tobacco smoke during pregnancy are unclear. We examined the association of maternal passive smoking during pregnancy and wheeze in children aged ≤2 years.Individual data of 27 993 mother–child pairs from 15 European birth cohorts were combined in pooled analyses taking into consideration potential confounders.Children with maternal exposure to passive smoking during pregnancy and no other smoking exposure were more likely to develop wheeze up to the age of 2 years (OR 1.11, 95% CI 1.03–1.20) compared with unexposed children. Risk of wheeze was further increased by children's postnatal passive smoke exposure in addition to their mothers' passive exposure during pregnancy (OR 1.29, 95% CI 1.19–1.40) and highest in children with both sources of passive exposure and mothers who smoked actively during pregnancy (OR 1.73, 95% CI 1.59–1.88). Risk of wheeze associated with tobacco smoke exposure was higher in children with an allergic versus nonallergic family history.Maternal passive smoking exposure during pregnancy is an independent risk factor for wheeze in children up to the age of 2 years. Pregnant females should avoid active and passive exposure to tobacco smoke for the benefit of their children's health.
Funder
Flight Attendant Medical Research Institute
European Commission
Publisher
European Respiratory Society (ERS)
Subject
Pulmonary and Respiratory Medicine
Reference46 articles.
1. Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries
2. US Department of Health and Human Services. The Health Consequences of Involuntary Exposure to Tobacco Smoke: a Report of the Surgeon General. Atlanta, US Department of Health and Human Services, Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2006. www.surgeongeneral.gov/library/secondhandsmoke/report/index.html Date last accessed: January 22, 2016. Last updated: 2006.
3. Prenatal tobacco smoke and postnatal secondhand smoke exposure and child neurodevelopment
4. Detrimental effects of tobacco smoke exposure during development on postnatal lung function and asthma
5. Trends in Childhood Asthma: Prevalence, Health Care Utilization, and Mortality
Cited by
101 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献