Pericarditis. Causes, Mechanisms of Development, Variants of Course and Therapeutic Approaches in Modern Conditions

Author:

Murkamilov I.ORCID,Aitbaev K.ORCID,Raimzhanov Z.ORCID,Duisheeva G.ORCID,Hakimov Sh.ORCID,Ymankulov D.ORCID,Yusupova Z.ORCID,Yusupova T.ORCID,Yusupov F.ORCID

Abstract

Under physiological conditions, the pericardial cavity contains serous fluid (15-50 ml), which belongs to the plasma ultrafiltrate and is visualized during echocardiography only in systole. The thickness of the pericardium in an adult averages 2 mm (1-3 mm). Inflammatory lesions of the pericardium with or without effusion into its cavity can act as an independent disease, and as a secondary manifestation of another pathological condition. Pericarditis of infectious (14-16%) and non-infectious (15-20%) nature, primary and secondary, acute, chronic and recurrent are commonly distinguished. The prevalence of acute and idiopathic recurrent pericarditis is 27.7 per 100,000 population and 5.4-8.1 per 100,000 population, respectively. Currently, idiopathic recurrent pericarditis belongs to polygenic autoinflammatory diseases, where an important role in the initiation of the pathologic process belongs to the inflammatory cytokine — interleukin-1 (β and α). The most characteristic manifestations of acute pericarditis are chest pain, dyspnea and fever. The article summarizes the main aspects of etiology, clinical manifestations, diagnosis and therapy of pericarditis, including the peculiarities of its treatment taking into account specific conditions. A clinical case demonstrated a case of acute effusion pericarditis with recurrence, which was characterized by rapid progression of heart failure symptoms, as well as systemic manifestations (anemia, hypercytokinemia, marked muscle weakness). The results of echocardiography allowed to identify the presence of pericardial effusion. Steroid and non-steroidal anti-inflammatory, anticoagulant and antibacterial therapy led to the disappearance of pericardial effusion and normalization of the activity of inflammatory markers in serum. However, in the dynamics of observation the attempt to suspend glucocorticoid therapy again led to fluid accumulation in the pericardium, which required continuation of steroidal and non-steroidal anti-inflammatory drugs.

Publisher

Publishing Center Science and Practice

Reference108 articles.

1. Arutyunov, G. P., Paleev, F. N., Tarlovskaya, E. I., Moiseeva, O. M., Arutyunov, A. G., Koziolova, N. A., ... & Irtyuga, O. B. (2023). Perikardity. Klinicheskie rekomendatsii 2022. Rossiiskii kardiologicheskii zhurnal, 28(3), 107-167. https://doi.org/10.15829/1560-4071-2023-5398

2. Chernyakova, N. S., Degtyar', N. N., Borshchev, A. V., Merkhi, A. V., & Ivanchura, G. S. (2017). Differentsial'nyi diagnoz perikardial'nogo vypota v praktike kardiologa. (in Russian). Nauchnyi vestnik zdravookhraneniya Kubani,(6), 56-75.

3. Sugak, A. B. (2009). Perikardity: etiologiya, klassifikatsiya, klinika, diagnostika, lechenie. Chast' 1. Voprosy sovremennoi pediatrii, 8(2), 77-84.

4. Gogin, E. E. (2001). Printsipy diagnostiki ostrykh perikarditov. Russkii meditsinskii zhurnal, (10), 411.

5. Nasonov, E. L., Sukmarova, Z. N., Popkova, T. V., & Belov, B. S. (2023). Problemy immunopatologii i perspektivy farmakoterapii idiopaticheskogo retsidiviruyushchego perikardita: primenenie ingibitora interleikina 1 (Anakinra). Nauchno-prakticheskaya revmatologiya, 61(1), 47-61. https://doi.org/10.47360/1995-4484-2023-47-61

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3