Affiliation:
1. Science and Innovation Centre, Astana, Kazakhstan
2. Department for Science and Gerontology, Medical Centre Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan
Abstract
Coronary artery disease (CAD) is one of the leading diseases contributing to mortality. Although it has a hereditary nature, its genetic etiology remains unclear. Recently, many studies showed genetic risk factors using genome-wide association studies, and gene variant association with CAD. Despite the recent breakthroughs on various single nucleotide polymorphisms (SNP) linked to CAD, encompassing genes affecting metabolic disorders, influencing endothelial and smooth muscle dysfunctions, leading to plaque formation and myocardial infarction, most of those SNPs` functions remain to be pinpointed. Many studies showed significant associations between rs4977574 polymorphism of cyclin-dependent protein kinase inhibitors antisense RNA 1 (CDKN2B-AS1) gene on CAD in various ethnic groups. This review discusses the potential link between the CDKN2B-AS1 gene rs4977574 polymorphism and CAD in the Kazakh population.
Publisher
JSC National Scientific Medical Research Center
Subject
Industrial and Manufacturing Engineering