Ca<sup>+2</sup> Channel Blockers-Reference-Cited by-同舟云学术

Ca⁺² Channel Blockers

Published:2024-02-18 Issue: Volume: Page:40-69
ISSN:2589-6989
Container-title:Medicinal Chemistry for Pharmacy Students
language:en
Short-container-title:

Author:

Rahman Taufiq¹,Faruk Khan M. O.²

Affiliation:

1. Department of Pharmacology, University of Cambridge, UK

2. University of Charleston, School of Pharmacy, Charleston, WV, USA

Abstract

This chapter is a comprehensive account of the medicinal chemistry of antihypertensive drugs, Ca2+-channel blockers (CCBs). It provides the mechanism of drug action and detailed structure-activity relationships (SAR) of the CCBs to give the knowledge base for pharmacists. After studying this chapter, students will be able to:• Comprehend the historical background of the CCBs. • Classify different types of voltage-gated Ca2+ channels (VGCCs) and their clinical significance. • Explain CCBs and their clinical significance. • Describe the mechanisms of action of CCBs at the molecular level including their binding modes against the VGCCs. • Describe the SAR of the different classes of CCBs. • Delineate clinical significance and therapeutic evaluations of these classes of drugs by solving case studies. • Articulate the discovery process of a few CCBs.

Publisher

BENTHAM SCIENCE PUBLISHERS

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