Affiliation:
1. Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology
and Sciences, Prayagraj, 211007, Uttar Pradesh, India
Abstract
Background:
Dracocephalum kotschyi Boiss is an important medicinal plant of
Asia, Europe and Iran. The therapeutic potential of Dracocephalum kotschyi has been mentioned
in traditional as well as in modern medicine, mainly due to its therapeutic effectiveness
against different types of human disorders and associated secondary complications.
Calycopterin is a flavonoid class phytochemical commonly called 5,4-dihydroxy-3,6,7,8-
tetramethoxyflavone, which has been isolated from Dracocephalum kotschyi. It is widely
used for the treatment of human disorders and associated secondary complications. Medicinal
importance and therapeutic potential of calycopterin was investigated in the present work
through scientific data analysis of different research works. Scientific data on calycopterin
published in different research articles were collected from PubMed, Google, Google Scholar,
Science Direct, SpringerLink, and Scopus and analyzed in the present work. Further, scientific
data was also collected from books and book chapters. Analytical data on calycopterin
was also collected and analyzed in the present work. Scientific data analysis of different
research work revealed the biological importance and therapeutic potential of calycopterin.
Calycopterin showed therapeutic effectiveness against different types of cancerous disorders,
including human prostate cancer, breast cancer, cervical cancer, lymphocyte proliferation
and hepatoblastoma cancer. Moreover, the biological effectiveness of calycopterin on neuroprotection
and Pseudomonas aeruginosa has also been discussed in the present work with
their pharmacokinetic parameters. Nevertheless, more scientific investigations must be conducted
to explore the health-beneficial aspects of calycopterin in medicine. Present work
signified the biological importance and therapeutic potential of calycopterin for the treatment
of human disorders and complications, including different types of cancerous disorders.
Publisher
Bentham Science Publishers Ltd.
Subject
Pharmacology (medical),Infectious Diseases,Drug Discovery