Therapeutic Potential of Ascorbic Acid in the Management of Alzheimer's Disease: An Update-Reference-Cited by-同舟云学术

Therapeutic Potential of Ascorbic Acid in the Management of Alzheimer's Disease: An Update

Published:2023-02 Issue:2 Volume:25 Page:196-212
ISSN:1389-2010
Container-title:Current Pharmaceutical Biotechnology
language:en
Short-container-title:CPB

Author:

Semwal Bhupesh Chander¹^ORCID,Singh Bhoopendra¹,Murti Yogesh¹,Singh Sonia¹

Affiliation:

1. Department of Pharmacy, Institute of Pharmaceutical Research GLA University, Mathura, U.P., 281406, India

Abstract

Background: Ascorbic acid is a potent natural antioxidant that protects against oxidative stress and performs various bodily functions. It is commonly found in fruits and vegetables. Objective: The manuscript has been written to provide valuable insights into ascorbic acid in managing Alzheimer's disease. Methods: The data has been gathered from web sources, including PubMed, Science Direct, Publons, Web of Science, and Scopus from 2000-2022 using AA, ascorbic acid, Alzheimer’s diseases, memory, dementia, and antioxidant Keywords. Results: In the present manuscript, we have summarized the impact of ascorbic acid and its possible mechanism in Alzheimer's disease by, outlining the information currently available on the behavioral and biochemical effects of ascorbic acid in animal models of Alzheimer's disease as well as its usage as a therapeutic agent to slow down the progression of Alzheimer disease in human beings. Oxidative stress plays a significant role in the advancement of AD. AA is a wellknown antioxidant that primarily reduces oxidative stress and produces protein aggregates, which may help decrease cognitive deficits in Alzheimer's disease. The current paper analyses of ascorbic acid revealed that deficiency of ascorbic acid adversely affects the central nervous system and leads to cognitive defects. However, the results of clinical studies are conflicting, but some of the studies suggested that supplementation of ascorbic acid improved cognitive deficits and decreased disease progression. Conclusion: Based on clinical and preclinical studies, it is observed that ascorbic acid supplementation improves cognitive deficits and protects the neurons from oxidative stress injury

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmaceutical Science,Biotechnology

Reference162 articles.

1. Nichols E.; Steinmetz J.D.; Vollset S.E.; Fukutaki K.; Chalek J.; Abd-Allah F.; Abdoli A.; Abualhasan A.; Abu-Gharbieh E.; Akram T.T.; Al Hamad H.; Alahdab F.; Alanezi F.M.; Alipour V.; Almustanyir S.; Amu H.; Ansari I.; Arabloo J.; Ashraf T.; Astell-Burt T.; Ayano G.; Ayuso-Mateos J.L.; Baig A.A.; Barnett A.; Barrow A.; Baune B.T.; Béjot Y.; Bezabhe W.M.M.; Bezabih Y.M.; Bhagavathula A.S.; Bhaskar S.; Bhattacharyya K.; Bijani A.; Biswas A.; Bolla S.R.; Boloor A.; Brayne C.; Brenner H.; Burkart K.; Burns R.A.; Cámera L.A.; Cao C.; Carvalho F.; Castro-de-Araujo L.F.S.; Catalá-López F.; Cerin E.; Chavan P.P.; Cherbuin N.; Chu D-T.; Costa V.M.; Couto R.A.S.; Dadras O.; Dai X.; Dandona L.; Dandona R.; De la Cruz-Góngora V.; Dhamnetiya D.; Dias da Silva D.; Diaz D.; Douiri A.; Edvardsson D.; Ekholuenetale M.; El Sayed I.; El-Jaafary S.I.; Eskandari K.; Eskandarieh S.; Esmaeilnejad S.; Fares J.; Faro A.; Farooque U.; Feigin V.L.; Feng X.; Fereshtehnejad S-M.; Fernandes E.; Ferrara P.; Filip I.; Fillit H.; Fischer F.; Gaidhane S.; Galluzzo L.; Ghashghaee A.; Ghith N.; Gialluisi A.; Gilani S.A.; Glavan I-R.; Gnedovskaya E.V.; Golechha M.; Gupta R.; Gupta V.B.; Gupta V.K.; Haider M.R.; Hall B.J.; Hamidi S.; Hanif A.; Hankey G.J.; Haque S.; Hartono R.K.; Hasaballah A.I.; Hasan M.T.; Hassan A.; Hay S.I.; Hayat K.; Hegazy M.I.; Heidari G.; Heidari-Soureshjani R.; Herteliu C.; Househ M.; Hussain R.; Hwang B-F.; Iacoviello L.; Iavicoli I.; Ilesanmi O.S.; Ilic I.M.; Ilic M.D.; Irvani S.S.N.; Iso H.; Iwagami M.; Jabbarinejad R.; Jacob L.; Jain V.; Jayapal S.K.; Jayawardena R.; Jha R.P.; Jonas J.B.; Joseph N.; Kalani R.; Kandel A.; Kandel H.; Karch A.; Kasa A.S.; Kassie G.M.; Keshavarz P.; Khan M.A.B.; Khatib M.N.; Khoja T.A.M.; Khubchandani J.; Kim M.S.; Kim Y.J.; Kisa A.; Kisa S.; Kivimäki M.; Koroshetz W.J.; Koyanagi A.; Kumar G.A.; Kumar M.; Lak H.M.; Leonardi M.; Li B.; Lim S.S.; Liu X.; Liu Y.; Logroscino G.; Lorkowski S.; Lucchetti G.; Lutzky Saute R.; Magnani F.G.; Malik A.A.; Massano J.; Mehndiratta M.M.; Menezes R.G.; Meretoja A.; Mohajer B.; Mohamed Ibrahim N.; Mohammad Y.; Mohammed A.; Mokdad A.H.; Mondello S.; Moni M.A.A.; Moniruzzaman M.; Mossie T.B.; Nagel G.; Naveed M.; Nayak V.C.; Neupane Kandel S.; Nguyen T.H.; Oancea B.; Otstavnov N.; Otstavnov S.S.; Owolabi M.O.; Panda-Jonas S.; Pashazadeh Kan F.; Pasovic M.; Patel U.K.; Pathak M.; Peres M.F.P.; Perianayagam A.; Peterson C.B.; Phillips M.R.; Pinheiro M.; Piradov M.A.; Pond C.D.; Potashman M.H.; Pottoo F.H.; Prada S.I.; Radfar A.; Raggi A.; Rahim F.; Rahman M.; Ram P.; Ranasinghe P.; Rawaf D.L.; Rawaf S.; Rezaei N.; Rezapour A.; Robinson S.R.; Romoli M.; Roshandel G.; Sahathevan R.; Sahebkar A.; Sahraian M.A.; Sathian B.; Sattin D.; Sawhney M.; Saylan M.; Schiavolin S.; Seylani A.; Sha F.; Shaikh M.A.; Shaji K.S.; Shannawaz M.; Shetty J.K.; Shigematsu M.; Shin J.I.; Shiri R.; Silva D.A.S.; Silva J.P.; Silva R.; Singh J.A.; Skryabin V.Y.; Skryabina A.A.; Smith A.E.; Soshnikov S.; Spurlock E.E.; Stein D.J.; Sun J.; Tabarés-Seisdedos R.; Thakur B.; Timalsina B.; Tovani-Palone M.R.; Tran B.X.; Tsegaye G.W.; Valadan Tahbaz S.; Valdez P.R.; Venketasubramanian N.; Vlassov V.; Vu G.T.; Vu L.G.; Wang Y-P.; Wimo A.; Winkler A.S.; Yadav L.; Yahyazadeh Jabbari S.H.; Yamagishi K.; Yang L.; Yano Y.; Yonemoto N.; Yu C.; Yunusa I.; Zadey S.; Zastrozhin M.S.; Zastrozhina A.; Zhang Z-J.; Murray C.J.L.; Vos T.; Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: An analysis for the Global Burden of Disease Study 2019. Lancet Public Health 2022,7(2),e105-e125

2. Varshney V.; Garabadu D.; Ang(1–7) exerts Nrf2-mediated neuroprotection against amyloid beta-induced cognitive deficits in rodents. Mol Biol Rep 2021,48(5),4319-4331

3. World Health Organization. Global status report on the public health response to dementia. 2021. Available From:

4. Bloom D.E.; 7 billion and counting. Science 2011,333(6042),562-569

5. Kaitelidou D.; Kalogeropoulou M.; Mougias A.; Galanis P.; Kontodimopoulos N.; Pasaloglou S.; Siskou O.; Socio-economic impact of Alzheimer’s disease in Greece: Pilot Study. Value Health 2013,16(7),A545