Advancements in Primary Alcohol Oxidation Leading to Carboxylic Acids: A Detailed Review

Abstract

This review article explores the direct oxidation of primary alcohols into carboxylic acids, highlighting its importance in organic synthesis for producing valuable chemicals in a sustainable and efficient manner. Carboxylic acids are widely employed in a wide range of applications, encompassing food preservatives, insecticides, dye intermediates, coatings, plasticizers, spices, flavors, scents, and a variety of industries such as polymers, solvents, and medications. This review article covers recent advancements in catalytic systems, including catalysts based on transition metals, organocatalysts, nanocatalysts, and electrochemical methods. It examines the impact of reaction conditions such as solvents, temperature, and substrate scope on these processes. The review also delves into mechanistic insights and recent developments in tandem and cascade reactions, aiming to provide a comprehensive understanding of current strategies and future research directions in this field.