The Regulatory Role of Circular RNAs as miRNA Sponges in Cervical Cancer-Reference-Cited by-同舟云学术

The Regulatory Role of Circular RNAs as miRNA Sponges in Cervical Cancer

Published:2023-11 Issue:3 Volume:18 Page:
ISSN:1574-3624
Container-title:Current Signal Transduction Therapy
language:en
Short-container-title:CST

Author:

Najafi Sajad¹,Ghaedrahmati Farhoodeh²,Abouali Gale Dari Mahrokh³,Farzaneh Maryam⁴,Mohammad Jafari Razieh³⁴

Affiliation:

1. Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2. Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3. Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

4. Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract

Abstract: Cervical cancer is ranked as the fourth most frequently diagnosed cancer and the fourth leading cause of cancer-related deaths among females. Cervical cancer is a complex disease influenced by various genetic, epigenetic, and environmental factors. While treatment options such as radiotherapy, chemotherapy, and hormonal therapy exist, the prognosis remains poor due to high rates of distant and lymphatic metastasis. Recent research has shed light on the role of non-coding RNAs (ncRNAs) in cervical cancer development, with circular RNAs (circRNAs) emerging as a potentially significant regulator of cellular processes. Through targeting miRNAs/mRNAs, circRNAs can impact cell growth and invasion in cervical cancer cells, making them a promising biomarker for diagnosis and treatment. This review provides an overview of the functional roles of circRNAs in the context of cervical cancer.

Publisher

Bentham Science Publishers Ltd.

Subject

Pharmacology (medical),Endocrinology

Reference106 articles.

1. Sung H.; Ferlay J.; Siegel R.L.; Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 can-cers in 185 countries. CA Cancer J Clin 2021,71(3),209-249

2. Hillemanns P.; Soergel P.; Hertel H.; Jentschke M.; Epidemiology and early detection of cervical cancer. Oncol Res Treat 2016,39(9),501-506

3. Staley H.; Shiraz A.; Shreeve N.; Bryant A.; Martin-Hirsch P.P.; Gajjar K.; Interventions targeted at women to encourage the uptake of cervical screening. Cochrane Database Syst Rev 2021,9(9),CD002834

4. Walboomers J.M.; Jacobs M.V.; Manos M.M.; Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999,189(1),12-19

5. de Martel C.; Plummer M.; Vignat J.; Franceschi S.; Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer 2017,141(4),664-670