Affiliation:
1. Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be
University, Shirpur, Maharashtra, 425405, India
Abstract
Abstract:
Transdermal Drug Delivery (TDD) is a non-painful way of systemically delivering medications
by applying a drug formulation to intact, healthy skin. The drug particles’ limitations, including the molecular
weight and hydrophilicity, preclude TDD from being exploited extensively. Microneedle arrays
(MNA) are an efficient way for medication delivery via the skin. Microneedles enhance medication administration.
Microneedles are either long, hollow, or coated. They are designed to target the skin as
quickly and safely as possible, without the use of chemical, nanoparticle, or hypodermic injections and
without requiring micro-pen or physical strategies. Solid microneedles include micropores, whereas hollow
microneedles provide a more profound passage into the dermis. Investigations have been conducted
on the use of dissolving microneedles for the delivery of vaccines, while coated microneedles have been
utilized to efficiently deliver vaccines. This paper attempts to provide a comprehensive summary of the
current state of MNA science, with a focus on methodologies, issues, implementations, and the types of
materials lately dispersed by such devices. In addition, some information regarding the components and
manufacturing methods is provided. Metals, silicone, ceramics, synthetic materials, and biodegradable
polymers, such as carbohydrates, can be utilized to manufacture microneedles.
Publisher
Bentham Science Publishers Ltd.
Subject
General Engineering,General Materials Science