The Microneedle Drug Delivery System and some Recent Obstacles in its Implementation

Author:

Dugad Bhagyesh1,Bhattacharya Sankha1ORCID

Affiliation:

1. Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM'S NMIMS Deemed-to-be University, Shirpur, Maharashtra, 425405, India

Abstract

Abstract: Transdermal Drug Delivery (TDD) is a non-painful way of systemically delivering medications by applying a drug formulation to intact, healthy skin. The drug particles’ limitations, including the molecular weight and hydrophilicity, preclude TDD from being exploited extensively. Microneedle arrays (MNA) are an efficient way for medication delivery via the skin. Microneedles enhance medication administration. Microneedles are either long, hollow, or coated. They are designed to target the skin as quickly and safely as possible, without the use of chemical, nanoparticle, or hypodermic injections and without requiring micro-pen or physical strategies. Solid microneedles include micropores, whereas hollow microneedles provide a more profound passage into the dermis. Investigations have been conducted on the use of dissolving microneedles for the delivery of vaccines, while coated microneedles have been utilized to efficiently deliver vaccines. This paper attempts to provide a comprehensive summary of the current state of MNA science, with a focus on methodologies, issues, implementations, and the types of materials lately dispersed by such devices. In addition, some information regarding the components and manufacturing methods is provided. Metals, silicone, ceramics, synthetic materials, and biodegradable polymers, such as carbohydrates, can be utilized to manufacture microneedles.

Publisher

Bentham Science Publishers Ltd.

Subject

General Engineering,General Materials Science

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3