Effect of Curcumin on the Head and Neck Squamous Cell Carcinoma Cell Line HN5-Reference-Cited by-全球学者库

Effect of Curcumin on the Head and Neck Squamous Cell Carcinoma Cell Line HN5

Published:2023-06 Issue:3 Volume:16 Page:374-380
ISSN:1874-4672
Container-title:Current Molecular Pharmacology
language:en
Short-container-title:CMP

Author:

Sharifi Simin¹,Khan Haroon²,Abdolahinia Elaheh Dalir³,Ahmadian Shahin⁴⁵,Bohlouli Sepideh⁶,Gharehbagh Faezeh Jafarmadar⁷,Jahandizi Negar Ghorbani⁸,Vahed Sepideh Zununi⁹,Saadat Yalda Rahbar⁹,Aghbali Amirala¹⁰,Dizaj Solmaz Maleki¹¹¹,Alsharif Khalaf F.¹²

Affiliation:

1. Dental and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2. Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan

3. Research Center for Pharmaceutical Nanotechnology (RCPN), Tabriz University of Medical Sciences, Tabriz, Iran

4. Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

5. Department of Biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran

6. Department of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran

7. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

8. Department of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran

9. Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

10. Oral and Maxillofacial Department of Pathology, Faculty of Dentistry, Tabriz, Iran

11. Department of Dental Biomaterials, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran

12. Department of Clinical Laboratory, College of Applied Medical Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

Abstract

Background: Curcumin has been isolated from the rhizomes of Curcuma longa. Over the years, it has shown outstanding therapeutic potential in various human disorders, including cancers. Objective: The aim is to study curcumin’s effects on the apoptosis signaling pathway in the head and neck squamous cell carcinoma (HNSCC) cell line HN5. Methods: The cytotoxicity of curcumin on HN5 cells were assessed. In addition, HN5 cells were also treated with curcumin to evaluate its effect on the caspase-8, -9, Bcl-2, Bax, and Stat3 gene expressions. Results: The results exhibited that cell viability reduced following curcumin treatment in a concentration- dependent manner. Curcumin treatment caused decreased expression of Bcl2, with simultaneous upregulation of the Bax/Bcl2 ratio. Curcumin increased caspase-9 expression, did not affect caspase-8, and decreased Stat3 expression. The induction of the mitochondria-dependent apoptosis pathway of curcumin happened by modulating the expression of Bcl2 and Bax genes, resulting in the caspase-9 activation. Furthermore, curcumin decreased the expression of the Stat3 in HN-5 cells. Conclusions: In conclusion, curcumin showed marked anticancer effects in the HN-5 cell line by modulating Stat-3; Bax/Bcl-2 expression in vitro.

Funder

Tabriz University of Medical Sciences

Taif University Researchers Supporting Program

Publisher

Bentham Science Publishers Ltd.

Subject

General Health Professions

Reference33 articles.

1. Sharifi S.; Zununi Vahed S.; Ahmadian E.; Maleki Dizaj S.; Abedi A.; Hosseiniyan Khatibi S.M.; Samiei M.; Stem cell therapy: Curcumin does the trick. Phytother Res 2019,33(11),2927-2937

2. Sharifi S.; Fathi N.; Memar M.Y.; Hosseiniyan Khatibi S.M.; Khalilov R.; Negahdari R.; Zununi Vahed S.; Maleki Dizaj S.; Anti-microbial activity of curcumin nanoformulations: New trends and future perspectives. Phytother Res 2020,34(8),1926-1946

3. Negahdari R.; Ghavimi M.A.; Barzegar A.; Memar M.Y.; Balazadeh L.; Bohlouli S.; Sharifi S.; Maleki Dizaj S.; Antibacterial effect of nanocurcumin inside the implant fixture: An in vitro study. Clin Exp Dent Res 2021,7(2),163-169

4. Ghavimi M.A.; Bani Shahabadi A.; Jarolmasjed S.; Memar M.Y.; Maleki Dizaj S.; Sharifi S.; Nanofibrous asymmetric collagen/curcumin membrane containing aspirin-loaded PLGA nanoparticles for guided bone regeneration. Sci Rep 2020,10(1),18200

5. Negahdari R.; Sharifi S.; Ghavimi M.A.; Memar M.Y.; Khaneshi B.; Maleki Dizaj S.; Eftekhari A.; Cucchiarini M.; Curcumin nanocrystals: Production, physicochemical assessment, and in vitro evaluation of the antimicrobial effects against bacterial loading of the implant fixture. Appl Sci (Basel) 2020,10,8356

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Curcumin, its derivatives, and their nanoformulations: Revolutionizing cancer treatment;Cell Biochemistry and Function;2024-01

2. Curcumin and analogues against head and neck cancer: From drug delivery to molecular mechanisms;Phytomedicine;2023-10

3. The Three-Dimensional In Vitro Cell Culture Models in the Study of Oral Cancer Immune Microenvironment;Cancers;2023-08-25

4. Effect of Curcumin-Loaded Mesoporous Silica Nanoparticles on the Head and Neck Cancer Cell Line, HN5;Current Issues in Molecular Biology;2022-10-27